Al-Amin, M. D., F. Mastrotto, A. Subrizi, M. Sen, T. Turunen, B. Arango-Gonzalez, M. Ueffing, A. Malfanti, A. Urtti, S. Salmaso, and P. Caliceti. Tailoring Surface Properties of Liposomes for Dexamethasone Intraocular Administration. Journal of Controlled Release, vol. 354, Feb. 2023, pp. 323–36, https://doi.org/10.1016/J.JCONREL.2023.01.027.


Ylä-Herttuala, E., T. Vuorio, S. Kettunen, S. Laidinen, S. Ylä-Herttuala, and T. Liimatainen. Lymphatic Insufficiency Leads to Distinct Myocardial Infarct Content Assessed by Magnetic Resonance TRAFFn, T1ρ and T2 Relaxation Times. Scientific Reports, vol. 13, no. 1, 2023, https://doi.org/10.1038/S41598-023-28219-6.


Hellinen, L., H. Hongisto, E. Ramsay, K. Kaarniranta, K.-S. Vellonen, H. Skottman, and M. Ruponen. Comparison of Barrier Properties of Outer Blood-Retinal Barrier Models – Human Stem Cell-Based Models as a Novel Tool for Ocular Drug Discovery. European Journal of Pharmaceutics and Biopharmaceutics, Feb. 2023, https://doi.org/10.1016/J.EJPB.2023.01.026.


Mäki-Mikola, E., P. Lauren, N. Uema, K. Kikuchi, Y. Takashima, T. Laaksonen, and T. Lajunen. Establishing a Simple Perfusion Cell Culture System for Light-Activated Liposomes. Scientific Reports, vol. 13, no. 1, Feb. 2023, p. 2050, https://doi.org/10.1038/S41598-023-29215-6.


Nousiainen, A., D. Schenkwein, and S. Ylä-Herttuala. Characterization of a New IN-I-PpoI Fusion Protein and a Homology-Arm Containing Transgene Cassette That Improve Transgene Expression Persistence and 28S rRNA Gene-Targeted Insertion of Lentiviral Vectors. PLOS ONE, vol. 18, no. 1, Jan. 2023, p. e0280894, https://doi.org/10.1371/JOURNAL.PONE.0280894.


Tonduru, A. K., S. K. Adla, K. M. Huttunen, T. Kronenberger, and A. Poso. Comparative Modelling of Organic Anion Transporting Polypeptides: Structural Insights and Comparison of Binding Modes. Molecules, vol. 27, no. 23, Dec. 2022, https://doi.org/10.3390/MOLECULES27238531.


Halonen J, Kärkkäinen J, Jäntti H, Martikainen T, Valtola A, Ellam S, Väliaho E, Santala E, Räsänen J, Juutilainen A, Mahlamäki V, Vasankari S, Vasankari T, Hartikainen J. Prevention of Atrial Fibrillation After Cardiac Surgery: A Review of Literature and Comparison of Different Treatment Modalities. Cardiol Rev. 2022 Dec 20. https://doi.org/10.1097/CRD.0000000000000499.


Rautaniemi, K., T. John, M. Richter, B. C. Huck, J. Zini, B. Loretz, C. M. Lehr, E. Vuorimaa-Laukkanen, E. Lisitsyna, and T. Laaksonen. Intracellular Dynamics of Extracellular Vesicles by Segmented Trajectory Analysis. Analytical Chemistry, vol. 94, no. 51, Dec. 2022, https://doi.org/10.1021/ACS.ANALCHEM.2C02928.


Imberg, L., S. Platte, C. Erbacher, C. G. Daniliuc, S. A. Kalinina, W. Dörner, A. Poso, U. Karst, and D. V. Kalinin. Amide-Functionalized 1,2,4-Triazol-5-Amines as Covalent Inhibitors of Blood Coagulation Factor XIIa and Thrombin. ACS Pharmacology & Translational Science, vol. 5, no. 12, Dec. 2022, https://doi.org/10.1021/ACSPTSCI.2C00204.


Blasiak, J., and K. Kaarniranta. Secretory Autophagy: A Turn Key for Understanding AMD Pathology and Developing New Therapeutic Targets? Expert Opinion on Therapeutic Targets, vol. 26, no. 10, 2022, https://doi.org/10.1080/14728222.2022.2157260.


Teppo, K., K. E. J. Airaksinen, J. Jaakkola, O. Halminen, M. Linna, J. Haukka, J. Putaala, P. Mustonen, J. Kinnunen, J. Hartikainen, A. L. Aro, and M. Lehto. Trends in Treatment and Outcomes of Atrial Fibrillation during 2007-2017 in Finland. European Heart Journal, Dec. 2022, https://doi.org/10.1093/EHJQCCO/QCAC086.


Merivaara, A., E. Koivunotko, K. Manninen, T. Kaseva, J. Monola, E. Salli, R. Koivuniemi, S. Savolainen, S. Valkonen, and M. Yliperttula. Stiffness-Controlled Hydrogels for 3D Cell Culture Models. Polymers, vol. 14, no. 24, Dec. 2022, https://doi.org/10.3390/POLYM14245530.


Mallick, R., and S. Ylä-Herttuala. Therapeutic Potential of VEGF-B in Coronary Heart Disease and Heart Failure: Dream or Vision? Cells, vol. 11, no. 24, Dec. 2022, https://doi.org/10.3390/CELLS11244134.


Dehouck, M. P., M. Tachikawa, Y. Hoshi, K. Omori, C. A. Maurage, G. Strecker, L. Dehouck, M. C. Boucau, Y. Uchida, F. Gosselet, T. Terasaki, and Y. Karamanos. Quantitative Targeted Absolute Proteomics for Better Characterization of an In Vitro Human Blood-Brain Barrier Model Derived from Hematopoietic Stem Cells. Cells, vol. 11, no. 24, Dec. 2022, https://doi.org/10.3390/CELLS11243963.


Kujala, A., E. Valkonen, H. Sallinen, L. Tuppurainen, H. Laakso, E. Ylä-Herttuala, T. Liimatainen, J. Kujala, O. Jokelainen, R. Sironen, M. Anttila, and S. Ylä-Herttuala. AAV8-Mediated sVEGFR2 and sVEGFR3 Gene Therapy Combined with Chemotherapy Reduces the Growth and Microvasculature of Human Ovarian Cancer and Prolongs the Survival in Mice. Frontiers in Medicine, vol. 9, Dec. 2022, https://doi.org/10.3389/FMED.2022.1018208.


Eriksson, R. A. E., T. Nieminen, L. Galibert, S. K. Peltola, P. Tikkanen, P. Käyhty, H. P. Lesch, S. Ylä-Herttuala, and K. J. Airenne. Optimized Riboswitch-Regulated AAV Vector for VEGF-B Gene Therapy. Frontiers in Medicine, vol. 9, Dec. 2022, https://doi.org/10.3389/FMED.2022.1052318.


Pajula, J., J. Lähteenvuo, M. Lähteenvuo, K. Honkonen, P. Halonen, O. P. Hätinen, A. Kuivanen, M. Heikkilä, J. Nurro, J. Hartikainen, and S. Ylä-Herttuala. Adenoviral VEGF-DΔN ΔC Gene Therapy for Myocardial Ischemia. Frontiers in Bioengineering and Biotechnology, vol. 10, Dec. 2022, https://doi.org/10.3389/FBIOE.2022.999226.


Balla, A., B. Tran, A. Valtari, P. Steven, C. Scarpellini, K. Augustyns, A. Urtti, K.-S. Vellonen, and M. Ruponen. A Novel Ferroptosis Inhibitor UAMC-3203, a Potential Treatment for Corneal Epithelial Wound. Pharmaceutics, vol. 15, no. 1, Dec. 2022, p. 118, https://doi.org/10.3390/PHARMACEUTICS15010118.


de Winther, M. P. J., M. Bäck, P. Evans, D. Gomez, I. Goncalves, H. F. Jørgensen, R. R. Koenen, E. Lutgens, G. D. Norata, E. Osto, L. Dib, M. Simons, K. Stellos, S. Ylä-Herttuala, H. Winkels, M.-L. Bochaton-Piallat, and C. Monaco. Translational Opportunities of Single-Cell Biology in Atherosclerosis. European Heart Journal, Dec. 2022, https://doi.org/10.1093/EURHEARTJ/EHAC686.


Bartuzi, D., E. Kędzierska, K. M. Targowska-Duda, O. Koszła, T. M. Wróbel, S. Jademyr, T. Karcz, K. Szczepańska, P. Stępnicki, O. Wronikowska-Denysiuk, G. Biała, J. Handzlik, J. L. Kristensen, A. Poso, and A. A. Kaczor. Funnel Metadynamics and Behavioral Studies Reveal Complex Effect of D2AAK1 Ligand on Anxiety-like Processes. Scientific Reports, vol. 12, no. 1, Dec. 2022, p. 21192, https://doi.org/10.1038/S41598-022-25478-7.


Liu, X., H. Tan, C. Rigoni, T. Hartikainen, N. Asghar, S. van Dijken, J. V. I. Timonen, B. Peng, and O. Ikkala. Magnetic Field-Driven Particle Assembly and Jamming for Bistable Memory and Response Plasticity. Science Advances, vol. 8, no. 45, Nov. 2022, https://doi.org/10.1126/SCIADV.ADC9394.


Heloterä, H., and K. Kaarniranta. A Linkage between Angiogenesis and Inflammation in Neovascular Age-Related Macular Degeneration. Cells, vol. 11, no. 21, Nov. 2022, p. 3453, https://doi.org/10.3390/CELLS11213453.


Ballo, H., F. Doghman, J. Hartikainen, A. Saraste, and J. Knuuti. Speckle-Tracking Echocardiography for Predicting Improvement of Myocardial Contractile Function after Revascularization: A Meta-Analysis of Prospective Trials. The International Journal of Cardiovascular Imaging, Nov. 2022, https://doi.org/10.1007/S10554-022-02753-2.


Bahrami, K., J. Järvinen, T. Laitinen, M. Reinisalo, P. Honkakoski, A. Poso, K. M. Huttunen, and J. Rautio. Structural Features Affecting the Interactions and Transportability of LAT1-Targeted Phenylalanine Drug Conjugates. Molecular Pharmaceutics, 2022, https://doi.org/10.1021/ACS.MOLPHARMACEUT.2C00594.


Babu, M., D. Devi, P. Mäkinen, T. Örd, E. Aavik, M. Kaikkonen, and S. Ylä-Herttuala. ApoA-I Nanotherapy Rescues Postischemic Vascular Maladaptation by Modulating Endothelial Cell and Macrophage Phenotypes in Type 2 Diabetic Mice. Arteriosclerosis, Thrombosis, and Vascular Biology, Nov. 2022, https://doi.org/10.1161/ATVBAHA.122.318196.


Díaz-Holguín, A., A. Rashidian, D. Pijnenburg, G. Monteiro Ferreira, A. Stefela, M. Kaspar, E. Kudova, A. Poso, R. van Beuningen, P. Pavek, and T. Kronenberger. When Two Become One: Conformational Changes in FXR/RXR Heterodimers Bound to Steroidal Antagonists. ChemMedChem, 2022, https://doi.org/10.1002/CMDC.202200556.


Lehto, M., J. Haukka, A. Aro, O. Halminen, J. Putaala, M. Linna, P. Mustonen, J. Kinnunen, E. Kouki, J. Niiranen, A. Luojus, P. Tiili, S. Itäinen-Strömberg, J. Hartikainen, and J. K. E. Airaksinen. Comprehensive Nationwide Incidence and Prevalence Trends of Atrial Fibrillation in Finland. Open Heart, vol. 9, no. 2, Nov. 2022, p. e002140, https://doi.org/10.1136/OPENHRT-2022-002140.


Boyce, M., Y. Xin, O. Chowdhury, P. Shang, H. Liu, V. Koontz, A. Strizhakova, M. Nemani, S. Hose, J. S. Zigler, M. Campbell, D. Sinha, J. T. Handa, K. Kaarniranta, J. Qian, and S. Ghosh. Microglia-Neutrophil Interactions Drive Dry AMD-like Pathology in a Mouse Model. Cells, vol. 11, no. 22, Nov. 2022, p. 3535, https://doi.org/10.3390/CELLS11223535.


Zhang, H., H. Zeng, A. Eklund, H. Guo, A. Priimagi, and O. Ikkala. Feedback-Controlled Hydrogels with Homeostatic Oscillations and Dissipative Signal Transduction. Nature Nanotechnology, Nov. 2022, https://doi.org/10.1038/S41565-022-01241-X.


Teppo, K., J. Jaakkola, F. Biancari, O. Halminen, M. Linna, J. Putaala, P. Mustonen, J. Kinnunen, S. Jolkkonen, M. Niemi, J. Hartikainen, K. E. J. Airaksinen, and M. Lehto. Socioeconomic Factors and Bleeding Events in Patients with Incident Atrial Fibrillation: A Finnish Nationwide Cohort Study. International Journal of Cardiology. Heart & Vasculature, vol. 43, Dec. 2022, p. 101131, https://doi.org/10.1016/J.IJCHA.2022.101131.


Mustonen, A. M., N. Lehmonen, S. Oikari, J. Capra, M. Raekallio, A. Mykkänen, T. Paakkonen, K. Rilla, T. Niemelä, and P. Nieminen. Counts of Hyaluronic Acid-Containing Extracellular Vesicles Decrease in Naturally Occurring Equine Osteoarthritis. Scientific Reports, vol. 12, no. 1, Dec. 2022, https://doi.org/10.1038/S41598-022-21398-8.


Katsumoto, K., S. Yennek, C. Chen, L. F. D. Silva, S. Traikov, D. Sever, A. Azad, J. Shan, S. Vainio, N. Ninov, S. Speier, and A. Grapin-Botton. Wnt4 Is Heterogeneously Activated in Maturing β-Cells to Control Calcium Signaling, Metabolism and Function. Nature Communications, vol. 13, no. 1, Dec. 2022, https://doi.org/10.1038/S41467-022-33841-5.


Rauniyar, K., S. Akhondzadeh, A. Gąciarz, J. Künnapuu, and M. Jeltsch. Bioactive VEGF-C from E. Coli. Scientific Reports, vol. 12, no. 1, Dec. 2022, https://doi.org/10.1038/S41598-022-22960-0.


Sharma, A., M. Meer, A. Dapkunas, A. Ihermann-Hella, S. Kuure, S. J. Vainio, D. Iber, and F. Naillat. FGF8 Induces Chemokinesis and Regulates Condensation of Mouse Nephron Progenitor Cells. Development, vol. 149, no. 21, Nov. 2022, https://doi.org/10.1242/DEV.201012.


Suoranta, T., N. Laham-Karam, and S. Ylä-Herttuala. Strategies to Improve Safety Profile of AAV Vectors. Frontiers in Molecular Medicine, vol. 0, Nov. 2022, p. 20, https://doi.org/10.3389/FMMED.2022.1054069.


Tuunainen, J., N. Sjöstedt, M. Vahteristo, J. Ellmén, M. Kuoppamäki, J. Rouru, and M. Yliperttula. Effect of Carbidopa Dose on Levodopa Pharmacokinetics With and Without Catechol-O-Methyltransferase Inhibition in Healthy Subjects. European Journal of Drug Metabolism and Pharmacokinetics, 2022, https://doi.org/10.1007/S13318-022-00800-W.


Kyykallio, H., A. V. S. Faria, R. Hartmann, J. Capra, K. Rilla, and P. R. M. Siljander. A Quick Pipeline for the Isolation of 3D Cell Culture-Derived Extracellular Vesicles. Journal of Extracellular Vesicles, vol. 11, no. 10, Oct. 2022, p. e12273, https://doi.org/10.1002/JEV2.12273.


Koivunotko, E., J. Snirvi, A. Merivaara, R. Harjumäki, S. Rautiainen, M. Kelloniemi, K. Kuismanen, S. Miettinen, M. Yliperttula, and R. Koivuniemi. Angiogenic Potential of Human Adipose-Derived Mesenchymal Stromal Cells in Nanofibrillated Cellulose Hydrogel. Biomedicines, vol. 10, no. 10, Oct. 2022, https://doi.org/10.3390/BIOMEDICINES10102584.


Bager, J.-E., A. Martín, J. Carbajosa Dalmau, A. Simon, J. L. Merino, B. Ritz, and J. E. K. Hartikainen. Vernakalant for Cardioversion of Recent-Onset Atrial Fibrillation in the Emergency Department: The SPECTRUM Study. Cardiology, Oct. 2022, pp. 1–12, https://doi.org/10.1159/000526831.


Csader, S., S. Korhonen, K. Kaarniranta, and U. Schwab. The Effect of Dietary Supplementations on Delaying the Progression of Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis. Nutrients, vol. 14, no. 20, Oct. 2022, https://doi.org/10.3390/NU14204273.


Ukkola, J., F. W. Pratiwi, S. Kankaanpää, S. Abdorahimzadeh, M. KarzarJeddi, P. Singh, A. Zhyvolozhnyi, O. Makieieva, S. Viitala, A. Samoylenko, H. Häggman, S. J. Vainio, C. Elbuken, and H. Liimatainen. Enrichment of Bovine Milk-Derived Extracellular Vesicles Using Surface-Functionalized Cellulose Nanofibers. Carbohydrate Polymers, vol. 297, Dec. 2022, p. 120069, https://doi.org/10.1016/J.CARBPOL.2022.120069.


Pereira, D. R., E. R. Silva, C. Carvalho-Maia, S. Monteiro-Reis, C. Lourenço, R. Calisto, R. J. Teixeira, L. E. Carlson, G. Bart, S. J. Vainio, M. G. F. Sales, C. Jerónimo, and R. Henrique. The Modulatory Role of Internet-Supported Mindfulness-Based Cognitive Therapy on Extracellular Vesicles and Psychological Distress in People Who Have Had Cancer: A Protocol for a Two-Armed Randomized Controlled Study. Trials, vol. 23, no. 1, Dec. 2022, https://doi.org/10.1186/S13063-022-06045-X.


Puranen, J., S. Koponen, T. Nieminen, I. Kanerva, E. Kokki, P. Toivanen, A. Urtti, S. Ylä-Herttuala, and M. Ruponen. Antiangiogenic AAV2 Gene Therapy with a Truncated Form of Soluble VEGFR-2 Reduces the Growth of Choroidal Neovascularization in Mice after Intravitreal Injection. Experimental Eye Research, vol. 224, Nov. 2022, p. 109237, https://doi.org/10.1016/J.EXER.2022.109237.


Blasiak, J., P. Sobczuk, E. Pawlowska, and K. Kaarniranta. Interplay between Aging and Other Factors of the Pathogenesis of Age-Related Macular Degeneration. Ageing Research Reviews, vol. 81, Nov. 2022, p. 101735, https://doi.org/10.1016/J.ARR.2022.101735.


Halmetoja, E., Nagy, I., Szabo, Z., Alakoski, T., Yrjölä, R., Vainio, L., Viitavaara, E., Lin, R., Rahtu-Korpela, L., Vainio, S., Kerkelä, R., & Magga, J. Wnt11 in regulation of physiological and pathological cardiac growth. FASEB Journal, 36(10), Oct. 2022, e22544. https://doi.org/10.1096/FJ.202101856RRRR


Mokkapati, S., et al. Lentiviral Interferon: A Novel Method for Gene Therapy in Bladder Cancer. Molecular Therapy – Oncolytics, vol. 26, Sept. 2022, pp. 141–57, https://doi.org/10.1016/J.OMTO.2022.06.005.


Korhonen, E. A., et al. Lymphangiogenesis Requires Ang2/Tie/PI3K Signaling for VEGFR3 Cell-Surface Expression. The Journal of Clinical Investigation, vol. 132, no. 15, Aug. 2022, https://doi.org/10.1172/JCI155478.


Mallick, R., E. Gurzeler, P. I. Toivanen, T. Nieminen, and S. Ylä-Herttuala. Novel Designed Proteolytically Resistant VEGF-B186R127S Promotes Angiogenesis in Mouse Heart by Recruiting Endothelial Progenitor Cells. Frontiers in Bioengineering and Biotechnology, vol. 10, Aug. 2022, https://doi.org/10.3389/FBIOE.2022.907538.


Tapio, J., R. Halmetoja, E. Y. Dimova, J. M. Mäki, A. Laitala, G. Walkinshaw, J. Myllyharju, R. Serpi, and P. Koivunen. Contribution of HIF-P4H Isoenzyme Inhibition to Metabolism Indicates Major Beneficial Effects Being Conveyed by HIF-P4H-2 Antagonism. The Journal of Biological Chemistry, vol. 298, no. 8, Aug. 2022, https://doi.org/10.1016/J.JBC.2022.102222.


Zhou, S., B. Peng, Y. Duan, K. Liu, O. Ikkala, and R. H. A. Ras. Bright and Photostable Fluorescent Metal Nanocluster Supraparticles from Invert Emulsions. Angewandte Chemie, Aug. 2022, https://doi.org/10.1002/ANIE.202210808.


Capra, J., K. Härkönen, H. Kyykallio, H. Vihinen, E. Jokitalo, and K. Rilla. Microscopic Characterization Reveals the Diversity of EVs Secreted by GFP-HAS3 Expressing MCF7 Cells. European Journal of Cell Biology, vol. 101, no. 3, Aug. 2022, https://doi.org/10.1016/J.EJCB.2022.151235.


Leikas, A. J., I. Hassinen, A. Kivelä, A. Hedman, H. Mussalo, S. Ylä-Herttuala, and J. E. K. Hartikainen. Intramyocardial Adenoviral Vascular Endothelial Growth Factor-D ∆N∆C Gene Therapy Does Not Induce Ventricular Arrhythmias. The Journal of Gene Medicine, vol. 24, no. 8, Aug. 2022, https://doi.org/10.1002/JGM.3437.


Som, A., A. Griffo, I. Chakraborty, H. Hähl, B. Mondal, A. Chakraborty, K. Jacobs, P. Laaksonen, O. Ikkala, T. Pradeep, and Nonappa. Strong and Elastic Membranes via Hydrogen Bonding Directed Self-Assembly of Atomically Precise Nanoclusters. Small, vol. 18, no. 34, Aug. 2022, https://doi.org/10.1002/SMLL.202201707.


Hytönen, J. P., and S. Ylä-Herttuala. Preclinical Evaluation of Coronary Artery Stents. Journal of Visualized Experiments : JoVE, no. 186, Aug. 2022, https://doi.org/10.3791/64038.


Ollonen, T., M. Kurkela, A. Laitakari, S. Sakko, H. Koivisto, J. Myllyharju, H. Tanila, R. Serpi, and P. Koivunen. Activation of the Hypoxia Response Protects Mice from Amyloid-β Accumulation. Cellular and Molecular Life Sciences : CMLS, vol. 79, no. 8, Aug. 2022, https://doi.org/10.1007/S00018-022-04460-6.


Koivisto, M., T. A. Tolvanen, T. Toimela, I. Miinalainen, A. Kiviaho, J. Kesseli, M. Nykter, L. Eklund, and T. Heinonen. Functional Human Cell-Based Vascularised Cardiac Tissue Model for Biomedical Research and Testing. Scientific Reports 2022 12:1, vol. 12, no. 1, Aug. 2022, pp. 1–13, https://doi.org/10.1038/s41598-022-17498-0.


Kettunen, S., A. K. Ruotsalainen, and S. Ylä-Herttuala. RNA Interference-Based Therapies for the Control of Atherosclerosis Risk Factors. Current Opinion in Cardiology, vol. 37, no. 4, July 2022, pp. 364–71, https://doi.org/10.1097/HCO.0000000000000972.


Jauhiainen, S., M. Kiema, M. Hedman, and J. P. Laakkonen. Large Vessel Cell Heterogeneity and Plasticity: Focus in Aortic Aneurysms. Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 42, no. 7, July 2022, pp. 811–18, https://doi.org/10.1161/ATVBAHA.121.316237.


Linko, V., H. Zhang, Nonappa, M. A. Kostiainen, and O. Ikkala. From Precision Colloidal Hybrid Materials to Advanced Functional Assemblies. Accounts of Chemical Research, vol. 55, no. 13, July 2022, pp. 1785–95, https://doi.org/10.1021/ACS.ACCOUNTS.2C00093.


Kalke, K., L. M. Lund, M. C. Nyman, A. A. Levanova, A. Urtti, M. M. Poranen, V. Hukkanen, and H. Paavilainen. Swarms of Chemically Modified Antiviral SiRNA Targeting Herpes Simplex Virus Infection in Human Corneal Epithelial Cells. PLoS Pathogens, vol. 18, no. 7, July 2022, https://doi.org/10.1371/JOURNAL.PPAT.1010688.


Huttunen, K. M., T. Terasaki, A. Urtti, A. B. Montaser, and Y. Uchida. Pharmacoproteomics of Brain Barrier Transporters and Substrate Design for the Brain Targeted Drug Delivery. Pharmaceutical Research, vol. 39, no. 7, July 2022, pp. 1363–92, https://doi.org/10.1007/S11095-022-03193-2.


Kiema, M., J. K. Sarin, S. P. Kauhanen, J. Torniainen, H. Matikka, E. S. Luoto, P. Jaakkola, P. Saari, T. Liimatainen, R. Vanninen, S. Ylä-Herttuala, M. Hedman, and J. P. Laakkonen. Wall Shear Stress Predicts Media Degeneration and Biomechanical Changes in Thoracic Aorta. Frontiers in Physiology, vol. 13, July 2022, p. 1354, https://doi.org/10.3389/FPHYS.2022.934941/BIBTEX.


Sadeghi, A., M. Ruponen, J. Puranen, S. Cao, R. Ridolfo, S. Tavakoli, E. Toropainen, T. Lajunen, V. P. Ranta, J. van Hest, and A. Urtti. Imaging, Quantitation and Kinetic Modelling of Intravitreal Nanomaterials. International Journal of Pharmaceutics, vol. 621, June 2022, https://doi.org/10.1016/J.IJPHARM.2022.121800.


Tavakoli, S., J. Puranen, S. Bahrpeyma, V. E. Lautala, S. Karumo, T. Lajunen, E. M. del Amo, M. Ruponen, and A. Urtti. Liposomal Sunitinib for Ocular Drug Delivery: A Potential Treatment for Choroidal Neovascularization. International Journal of Pharmaceutics, vol. 620, May 2022, https://doi.org/10.1016/J.IJPHARM.2022.121725.


Zini, J., H. Saari, P. Ciana, T. Viitala, A. Lõhmus, J. Saarinen, and M. Yliperttula. Infrared and Raman Spectroscopy for Purity Assessment of Extracellular Vesicles. European Journal of Pharmaceutical Sciences, vol. 172, May 2022, https://doi.org/10.1016/J.EJPS.2022.106135.


Tavakoli, S., J. Puranen, S. Bahrpeyma, V. E. Lautala, S. Karumo, T. Lajunen, E. M. del Amo, M. Ruponen, and A. Urtti. Liposomal Sunitinib for Ocular Drug Delivery: A Potential Treatment for Choroidal Neovascularization. International Journal of Pharmaceutics, vol. 620, May 2022, https://doi.org/10.1016/J.IJPHARM.2022.121725.


Sissala, N., E. Myllymäki, F. Mohr, R. Halmetoja, P. Kuvaja, E. Y. Dimova, and P. Koivunen. Hypoxia Ameliorates Maternal Diet-Induced Insulin Resistance during Pregnancy While Having a Detrimental Effect on the Placenta. Physiological Reports, vol. 10, no. 9, May 2022, https://doi.org/10.14814/PHY2.15302.


Bellenguez, C., et al. New Insights into the Genetic Etiology of Alzheimer’s Disease and Related Dementias. Nature Genetics, vol. 54, no. 4, Apr. 2022, pp. 412–36, https://doi.org/10.1038/S41588-022-01024-Z.


Merivaara, A., J. Kekkonen, J. Monola, E. Koivunotko, M. Savolainen, T. Silvast, K. Svedström, A. Diaz, M. Holler, O. Korhonen, M. Yliperttula, and S. Valkonen. Near-Infrared Analysis of Nanofibrillated Cellulose Aerogel Manufacturing. International Journal of Pharmaceutics, vol. 617, Apr. 2022, https://doi.org/10.1016/J.IJPHARM.2022.121581.


Kaarniranta, K., J. Blasiak, P. Liton, M. Boulton, D. J. Klionsky, and D. Sinha. Autophagy in Age-Related Macular Degeneration. Autophagy, 2022, https://doi.org/10.1080/15548627.2022.2069437.


Aaltonen, N., H. Kyykallio, S. Tollis, J. Capra, J. M. Hartikainen, J. Matilainen, S. Oikari, and K. Rilla. MCF10CA Breast Cancer Cells Utilize Hyaluronan-Coated EV-Rich Trails for Coordinated Migration. Frontiers in Oncology, vol. 12, Apr. 2022, https://doi.org/10.3389/FONC.2022.869417.


Mustonen, E. K., T. Pantsar, A. Rashidian, J. Reiner, M. Schwab, S. Laufer, and O. Burk. Target Hopping from Protein Kinases to PXR: Identification of Small-Molecule Protein Kinase Inhibitors as Selective Modulators of Pregnane X Receptor from TüKIC Library. Cells, vol. 11, no. 8, Apr. 2022, https://doi.org/10.3390/CELLS11081299.


Raheem, D., O. B. Oluwole, L. Faven, F. A. Orji, M. Junttila, E. Rainosalo, S. B. Kosoko, A. Olukosi, S. Vainio, A. A. Olapade, M. P. Okoh, and O. M. Oyeku. Partnership for International Development: Finland-Nigeria Conference on Climate, Food, Health and Entrepreneurship. International Journal of Environmental Research and Public Health, vol. 19, no. 6, Mar. 2022, https://doi.org/10.3390/IJERPH19063375.


Purola, P., K. Kaarniranta, M. Ojamo, M. Gissler, and H. Uusitalo. Visual Impairment Due to Age-Related Macular Degeneration during 40 Years in Finland and the Impact of Novel Therapies. Acta Ophthalmologica, 2022, https://doi.org/10.1111/AOS.15224.


Siimes, S., N. Järveläinen, H. Korpela, and S. Ylä-Herttuala. Endocardial Gene Delivery Using NOGA Catheter System. Methods in Molecular Biology, vol. 2573, 2022, pp. 179–87, https://doi.org/10.1007/978-1-0716-2707-5_14.


Mitra, A. P., et al. Antiadenovirus Antibodies Predict Response Durability to Nadofaragene Firadenovec Therapy in BCG-Unresponsive Non–Muscle-Invasive Bladder Cancer: Secondary Analysis of a Phase 3 Clinical Trial. European Urology, vol. 81, no. 3, 2022, https://doi.org/10.1016/j.eururo.2021.12.009.


Korpela, H., J. Lampela, J. Airaksinen, N. Järveläinen, S. Siimes, K. Valli, T. Nieminen, M. Turunen, M. Grönman, A. Saraste, J. Knuuti, M. Hakulinen, P. Poutiainen, V. Kärjä, J. Nurro, and S. Ylä-Herttuala. AAV2-VEGF-B Gene Therapy Failed to Induce Angiogenesis in Ischemic Porcine Myocardium Due to Inflammatory Responses. Gene Therapy, 2022, https://doi.org/10.1038/s41434-022-00322-9.


Jaiswal, A. K., A. Hokkanen, M. Kapulainen, A. Khakalo, Nonappa, O. Ikkala, and H. Orelma. Carboxymethyl Cellulose (CMC) Optical Fibers for Environment Sensing and Short-Range Optical Signal Transmission. ACS Applied Materials and Interfaces, vol. 14, no. 2, 2022, https://doi.org/10.1021/acsami.1c22227.


Dörres, T., M. Bartkiewicz, K. Herrmann, M. Schöttle, D. Wagner, Z. Wang, O. Ikkala, M. Retsch, G. Fytas, and J. Breu. Nanoscale-Structured Hybrid Bragg Stacks with Orientation- and Composition-Dependent Mechanical and Thermal Transport Properties: Implications for Nacre Mimetics and Heat Management Applications. ACS Applied Nano Materials, vol. 5, no. 3, 2022, https://doi.org/10.1021/acsanm.2c00061.


Shevchenko, E., and T. Pantsar. Regulatory Spine RS3 Residue of Protein Kinases: A Lipophilic Bystander or a Decisive Element in the Small-Molecule Kinase Inhibitor Binding? Biochemical Society Transactions, vol. 50, no. 1, 2022, https://doi.org/10.1042/BST20210837.


Isokuortti, J., I. Kiiski, T. Sikanen, N. Durandin, and T. Laaksonen. Microfluidic Oxygen Tolerability Screening of Nanocarriers for Triplet Fusion Photon Upconversion. Journal of Materials Chemistry. C, vol. 10, no. 12, Feb. 2022, pp. 4871–77, https://doi.org/10.1039/D2TC00156J.


Rashidian, A., E. K. Mustonen, T. Kronenberger, M. Schwab, O. Burk, S. A. Laufer, and T. Pantsar. Discrepancy in Interactions and Conformational Dynamics of Pregnane X Receptor (PXR) Bound to an Agonist and a Novel Competitive Antagonist. Computational and Structural Biotechnology Journal, vol. 20, Jan. 2022, pp. 3004–18, https://doi.org/10.1016/J.CSBJ.2022.06.020.


Kicková, E., A. Sadeghi, J. Puranen, S. Tavakoli, M. Sen, V. P. Ranta, B. Arango-Gonzalez, S. Bolz, M. Ueffing, S. Salmaso, P. Caliceti, E. Toropainen, M. Ruponen, and A. Urtti. Pharmacokinetics of Pullulan–Dexamethasone Conjugates in Retinal Drug Delivery. Pharmaceutics, vol. 14, no. 1, 2022, https://doi.org/10.3390/pharmaceutics14010012.


Huttunen, K. M., T. Terasaki, A. Urtti, A. B. Montaser, and Y. Uchida. Pharmacoproteomics of Brain Barrier Transporters and Substrate Design for the Brain Targeted Drug Delivery. Pharmaceutical Research, vol. 39, no. 7, 2022, https://doi.org/10.1007/s11095-022-03193-2.


Kraatari-Tiri, M., et al. HIDEA Syndrome Is Caused by Biallelic, Pathogenic, Rare or Founder P4HTM Variants Impacting the Active Site or the Overall Stability of the P4H-TM Protein. Clinical Genetics, 2022, https://doi.org/10.1111/CGE.14203.


Byts, N., S. Sharma, T. Malm, M. Kaakinen, P. Korhonen, L. Jaakkonen, M. Keuters, M. Huuskonen, I. Pietilä, J. Koistinaho, P. Koivunen, and J. Myllyharju. Inactivation of Mouse Transmembrane Prolyl 4-Hydroxylase Increases Blood Brain Barrier Permeability and Ischemia-Induced Cerebral Neuroinflammation. Journal of Biological Chemistry, vol. 298, no. 3, 2022, https://doi.org/10.1016/j.jbc.2022.101721.


Sissala, N., S. Mustaniemi, E. Kajantie, M. Vääräsmäki, and P. Koivunen. Higher Hemoglobin Levels Are an Independent Risk Factor for Gestational Diabetes. Scientific Reports, vol. 12, no. 1, 2022, https://doi.org/10.1038/s41598-022-05801-y.


Elamaa, H., M. Kaakinen, M. Nätynki, Z. Szabo, V. P. Ronkainen, V. Äijälä, J. M. Mäki, R. Kerkelä, J. Myllyharju, and L. Eklund. PHD2 Deletion in Endothelial or Arterial Smooth Muscle Cells Reveals Vascular Cell Type-Specific Responses in Pulmonary Hypertension and Fibrosis. Angiogenesis, vol. 25, no. 2, 2022, https://doi.org/10.1007/s10456-021-09828-z.


Richards, M., E. Nwadozi, S. Pal, P. Martinsson, M. Kaakinen, M. Gloger, E. Sjöberg, K. Koltowska, C. Betsholtz, L. Eklund, S. Nordling, and L. Claesson-Welsh. Claudin5 Protects the Peripheral Endothelial Barrier in an Organ and Vessel-Type-Specific Manner. ELife, vol. 11, 2022, https://doi.org/10.7554/ELIFE.78517.


Paul, T., S. Vainio, and J. Roning. Detection of Intra-Family Coronavirus Genome Sequences through Graphical Representation and Artificial Neural Network. Expert Systems with Applications, vol. 194, 2022, https://doi.org/10.1016/j.eswa.2022.116559.


Zini, J., H. Saari, P. Ciana, T. Viitala, A. Lõhmus, J. Saarinen, and M. Yliperttula. Infrared and Raman Spectroscopy for Purity Assessment of Extracellular Vesicles. European Journal of Pharmaceutical Sciences, vol. 172, 2022, https://doi.org/10.1016/j.ejps.2022.106135.


Merivaara, A., J. Kekkonen, J. Monola, E. Koivunotko, M. Savolainen, T. Silvast, K. Svedström, A. Diaz, M. Holler, O. Korhonen, M. Yliperttula, and S. Valkonen. Near-Infrared Analysis of Nanofibrillated Cellulose Aerogel Manufacturing. International Journal of Pharmaceutics, vol. 617, 2022, https://doi.org/10.1016/j.ijpharm.2022.121581.


Tähtinen, V., V. Gulumkar, S. K. Maity, A. M. Yliperttula, S. Siekkinen, T. Laine, E. Lisitsyna, I. Haapalehto, T. Viitala, E. Vuorimaa-Laukkanen, M. Yliperttula, and P. Virta. Assembly of Bleomycin Saccharide-Decorated Spherical Nucleic Acids. Bioconjugate Chemistry, vol. 33, no. 1, 2022, https://doi.org/10.1021/acs.bioconjchem.1c00539.


Rak-Raszewska, A., G. Reint, F. Geiger, F. Naillat, and S. J. Vainio. Deciphering the Minimal Quantity of Mouse Primary Cells to Undergo Nephrogenesis Ex Vivo. Developmental Dynamics, vol. 251, no. 3, 2022, https://doi.org/10.1002/dvdy.418.


Mazumder, A. H., et al. Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder. Brain Sciences, vol. 11, no. 11, Nov. 2021, https://doi.org/10.3390/BRAINSCI11111422.


Leikas, A. J., I. Hassinen, A. Hedman, A. Kivelä, S. Ylä-Herttuala, and J. E. K. Hartikainen. Long-Term Safety and Efficacy of Intramyocardial Adenovirus-Mediated VEGF-DΔNΔC Gene Therapy Eight-Year Follow-up of Phase I KAT301 Study. Gene Therapy, vol. 29, no. 5, 2022, https://doi.org/10.1038/s41434-021-00295-1.


Rousou, C., C. C. L. Schuurmans, A. Urtti, E. Mastrobattista, G. Storm, C. Moonen, K. Kaarniranta, and R. Deckers. Ultrasound and Microbubbles for the Treatment of Ocular Diseases: From Preclinical Research towards Clinical Application. Pharmaceutics, vol. 13, no. 11, 2021, https://doi.org/10.3390/pharmaceutics13111782.


Künnapuu, J., and M. Jeltsch. Outside in and Brakes off for Lymphatic Growth. Science Signaling, vol. 14, no. 695, 2021, https://doi.org/10.1126/scisignal.abj5058.


Pulkkinen, H. H., M. Kiema, J. P. Lappalainen, A. Toropainen, M. Beter, A. Tirronen, L. Holappa, H. Niskanen, M. U. Kaikkonen, S. Ylä-Herttuala, and J. P. Laakkonen. BMP6/TAZ-Hippo Signaling Modulates Angiogenesis and Endothelial Cell Response to VEGF. Angiogenesis, vol. 24, no. 1, 2021, https://doi.org/10.1007/s10456-020-09748-4.


Heise, K., E. Kontturi, Y. Allahverdiyeva, T. Tammelin, M. B. Linder, Nonappa, and O. Ikkala. Nanocellulose: Recent Fundamental Advances and Emerging Biological and Biomimicking Applications. Advanced Materials, vol. 33, no. 3, 2021, https://doi.org/10.1002/adma.202004349.


Hynninen, V., S. Chandra, S. Das, M. Amini, Y. Dai, S. Lepikko, P. Mohammadi, S. Hietala, R. H. A. Ras, Z. Sun, O. Ikkala, and Nonappa. Luminescent Gold Nanocluster-Methylcellulose Composite Optical Fibers with Low Attenuation Coefficient and High Photostability. Small, vol. 17, no. 27, 2021, https://doi.org/10.1002/smll.202005205.


Munne, P. M., et al. Compressive Stress-Mediated P38 Activation Required for ERα + Phenotype in Breast Cancer. Nature Communications, vol. 12, no. 1, 2021, https://doi.org/10.1038/s41467-021-27220-9.


Cherian, T., F. Sohrabi, C. Rigoni, O. Ikkala, and J. V. I. Timonen. Electroferrofluids with Nonequilibrium Voltage-Controlled Magnetism, Diffuse Interfaces, and Patterns. Science Advances, vol. 7, no. 52, 2021, https://doi.org/10.1126/sciadv.abi8990.


Guryanov, I., T. Tennikova, and A. Urtti. Peptide Inhibitors of Vascular Endothelial Growth Factor a: Current Situation and Perspectives. Pharmaceutics, vol. 13, no. 9, 2021, https://doi.org/10.3390/pharmaceutics13091337.


Sen, M., M. Al-Amin, E. Kicková, A. Sadeghi, J. Puranen, A. Urtti, P. Caliceti, S. Salmaso, B. Arango-Gonzalez, and M. Ueffing. Retinal Neuroprotection by Controlled Release of a VCP Inhibitor from Self-Assembled Nanoparticles. Journal of Controlled Release, vol. 339, 2021, https://doi.org/10.1016/j.jconrel.2021.09.039.


Pretto, C., M. Tang, M. Chen, H. Xu, A. Subrizi, A. Urtti, and J. C. M. van Hest. Cowpea Chlorotic Mottle Virus-Like Particles as Potential Platform for Antisense Oligonucleotide Delivery in Posterior Segment Ocular Diseases. Macromolecular Bioscience, vol. 21, no. 8, 2021, https://doi.org/10.1002/mabi.202100095.


Junnuthula, V., A. S. Boroujeni, S. Cao, S. Tavakoli, R. Ridolfo, E. Toropainen, M. Ruponen, J. C. M. van Hest, and A. Urtti. Intravitreal Polymeric Nanocarriers with Long Ocular Retention and Targeted Delivery to the Retina and Optic Nerve Head Region. Pharmaceutics, vol. 13, no. 4, 2021, https://doi.org/10.3390/pharmaceutics13040445.


Ridolfo, R., S. Tavakoli, V. Junnuthula, D. S. Williams, A. Urtti, and J. C. M. Van Hest. Exploring the Impact of Morphology on the Properties of Biodegradable Nanoparticles and Their Diffusion in Complex Biological Medium. Biomacromolecules, vol. 22, no. 1, 2021, https://doi.org/10.1021/acs.biomac.0c00726.


Feola, S., et al. PeptiCHIP: A Microfluidic Platform for Tumor Antigen Landscape Identification. ACS Nano, vol. 15, no. 10, 2021, https://doi.org/10.1021/acsnano.1c04371.


Suoranta, T., N. Laham-Karam, and S. Ylä-Herttuala. Optimized Protocol for Accurate Titration of Adeno-Associated Virus Vectors. Human Gene Therapy, vol. 32, no. 19–20, 2021, https://doi.org/10.1089/hum.2020.318.


Koistinen, H., J. Künnapuu, and M. Jeltsch. Klk3 in the Regulation of Angiogenesis—Tumorigenic or Not? International Journal of Molecular Sciences, vol. 22, no. 24, 2021, https://doi.org/10.3390/ijms222413545.


Tapio, J., H. Vähänikkilä, Y. A. Kesäniemi, O. Ukkola, and P. Koivunen. Higher Hemoglobin Levels Are an Independent Risk Factor for Adverse Metabolism and Higher Mortality in a 20-Year Follow-Up. Scientific Reports, vol. 11, no. 1, 2021, https://doi.org/10.1038/s41598-021-99217-9.


Auvinen, J., et al. Systematic Evaluation of the Association between Hemoglobin Levels and Metabolic Profile Implicates Beneficial Effects of Hypoxia. Science Advances, vol. 7, no. 29, 2021, https://doi.org/10.1126/sciadv.abi4822.


Määttä, J., R. Serpi, S. Hörkkö, V. Izzi, J. Myllyharju, E. Y. Dimova, and P. Koivunen. Genetic Ablation of Transmembrane Prolyl 4-Hydroxylase Reduces Atherosclerotic Plaques in Mice. Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 41, no. 7, 2021, https://doi.org/10.1161/ATVBAHA.121.316034.


Dengler, F., S. Sova, A. M. Salo, J. M. Mäki, P. Koivunen, and J. Myllyharju. Expression and Roles of Individual Hif Prolyl 4-Hydroxylase Isoenzymes in the Regulation of the Hypoxia Response Pathway along the Murine Gastrointestinal Epithelium. International Journal of Molecular Sciences, vol. 22, no. 8, 2021, https://doi.org/10.3390/ijms22084038.


Byts, N., S. Sharma, J. Laurila, P. Paudel, I. Miinalainen, V. P. Ronkainen, R. Hinttala, K. Törnquist, P. Koivunen, and J. Myllyharju. Transmembrane Prolyl 4-Hydroxylase Is a Novel Regulator of Calcium Signaling in Astrocytes. ENeuro, vol. 8, no. 1, 2021, https://doi.org/10.1523/ENEURO.0253-20.2020.


Myllykoski, M., A. Sutinen, M. K. Koski, J. P. Kallio, A. Raasakka, J. Myllyharju, R. K. Wierenga, and P. Koivunen. Structure of Transmembrane Prolyl 4-Hydroxylase Reveals Unique Organization of EF and Dioxygenase Domains. Journal of Biological Chemistry, vol. 296, 2021, https://doi.org/10.1074/JBC.RA120.016542.


Koivunotko, E., A. Merivaara, A. Niemelä, S. Valkonen, K. Manninen, H. Mäkinen, M. Viljanen, K. Svedström, A. Diaz, M. Holler, J. Zini, L. Paasonen, O. Korhonen, S. Huotari, A. Koivuniemi, and M. Yliperttula. Molecular Insights on Successful Reconstitution of Freeze-Dried Nanofibrillated Cellulose Hydrogel. ACS Applied Bio Materials, 2021, https://doi.org/10.1021/acsabm.1c00739.


Zini, J., J. Kekkonen, V. A. Kaikkonen, T. Laaksonen, P. Keränen, T. Talala, A. J. Mäkynen, M. Yliperttula, and I. Nissinen. Drug Diffusivities in Nanofibrillar Cellulose Hydrogel by Combined Time-Resolved Raman and Fluorescence Spectroscopy. Journal of Controlled Release, vol. 334, 2021, https://doi.org/10.1016/j.jconrel.2021.04.032.


Koponen, S., E. Kokki, K. Kinnunen, and S. Ylä-Herttuala. Viral-Vector-Delivered Anti-Angiogenic Therapies to the Eye. Pharmaceutics, vol. 13, no. 2, 2021, https://doi.org/10.3390/pharmaceutics13020219.


Korpela, H., N. Järveläinen, S. Siimes, J. Lampela, J. Airaksinen, K. Valli, M. Turunen, J. Pajula, J. Nurro, and S. Ylä-Herttuala. Gene Therapy for Ischaemic Heart Disease and Heart Failure. Journal of Internal Medicine, vol. 290, no. 3, 2021, https://doi.org/10.1111/joim.13308.


Järveläinen, N., P. Halonen, J. Nurro, O. P. Hätinen, H. Korpela, P. Mäkinen, L. M. Gan, R. Fritsche-Danielson, and S. Ylä-Herttuala. Citrate-Saline-Formulated MRNA Delivery into the Heart Muscle with an Electromechanical Mapping and Injection Catheter Does Not Lead to Therapeutic Effects in a Porcine Chronic Myocardial Ischemia Model. Human Gene Therapy, vol. 32, no. 19–20, 2021, https://doi.org/10.1089/hum.2021.149.


Korpela, H., S. Siimes, and S. Ylä-Herttuala. Large Animal Model for Evaluating the Efficacy of the Gene Therapy in Ischemic Heart. Journal of Visualized Experiments, vol. 2021, no. 175, 2021, https://doi.org/10.3791/62833.


Korpela, H., O. P. Hätinen, T. Nieminen, R. Mallick, P. Toivanen, J. Airaksinen, K. Valli, M. Hakulinen, P. Poutiainen, J. Nurro, and S. Ylä-Herttuala. Adenoviral VEGF-B186R127S Gene Transfer Induces Angiogenesis and Improves Perfusion in Ischemic Heart. IScience, vol. 24, no. 12, 2021, https://doi.org/10.1016/j.isci.2021.103533.


Leikas, A. J., N. Laham-Karam, E. Agtereek, H. M. Peltonen, T. Selander, P. Korpisalo, L. Holappa, J. E. K. Hartikainen, T. Heikura, and S. Ylä-Herttuala. Efficacy and Safety of Clinical-Grade Human Vascular Endothelial Growth Factor-D∆N∆C Gene Therapy Containing Residual Replication-Competent Adenoviruses. Human Gene Therapy, vol. 32, no. 13–14, 2021, https://doi.org/10.1089/hum.2020.299.


Mushimiyimana, I., V. Tomas Bosch, H. Niskanen, N. Downes, P. Moreau, K. Hartigan, S. Ylä-Herttuala, N. Laham-Karam, and M. U. Kaikkonen. Genomic Landscapes of Non-Coding RNAs Regulating VEGFA and VEGFC Expression in Endothelial Cells . Molecular and Cellular Biology, Apr. 2021, https://doi.org/10.1128/mcb.00594-20.


Mushimiyimana, I., H. Niskanen, M. Beter, J. P. Laakkonen, M. U. Kaikkonen, S. Ylä-Herttuala, and N. Laham-Karam. Characterization of a Functional Endothelial Super-Enhancer That Regulates ADAMTS18 and Angiogenesis. Nucleic Acids Research, vol. 49, no. 14, 2021, pp. 8078–96, https://doi.org/10.1093/nar/gkab633.


Kari, O. K., S. Tavakoli, P. Parkkila, S. Baan, R. Savolainen, T. Ruoslahti, N. G. Johansson, J. Ndika, H. Alenius, T. Viitala, A. Urtti, and T. Lajunen. Light-Activated Liposomes Coated with Hyaluronic Acid as a Potential Drug Delivery System. Pharmaceutics, vol. 12, no. 8, 2020, https://doi.org/10.3390/pharmaceutics12080763.


Losman, J. A., P. Koivunen, and W. G. Kaelin. 2-Oxoglutarate-Dependent Dioxygenases in Cancer. Nature Reviews Cancer, vol. 20, no. 12, 2020, https://doi.org/10.1038/s41568-020-00303-3.


Settelmeier, S., T. Schreiber, J. Mäki, N. Byts, P. Koivunen, J. Myllyharju, J. Fandrey, and S. Winning. Prolyl Hydroxylase Domain 2 Reduction Enhances Skeletal Muscle Tissue Regeneration after Soft Tissue Trauma in Mice. PLoS ONE, vol. 15, no. 5, 2020, https://doi.org/10.1371/journal.pone.0233261.


Laitakari, A., J. Tapio, K. A. Mäkelä, K. H. Herzig, F. Dengler, H. Gylling, G. Walkinshaw, J. Myllyharju, E. Y. Dimova, R. Serpi, and P. Koivunen. HIF-P4H-2 Inhibition Enhances Intestinal Fructose Metabolism and Induces Thermogenesis Protecting against NAFLD. Journal of Molecular Medicine, vol. 98, no. 5, 2020, https://doi.org/10.1007/s00109-020-01903-0.


Laitakari, A., R. Huttunen, P. Kuvaja, P. Hannuksela, Z. Szabo, M. Heikkilä, R. Kerkelä, J. Myllyharju, E. Y. Dimova, R. Serpi, and P. Koivunen. Systemic Long-Term Inactivation of Hypoxia-Inducible Factor Prolyl 4-Hydroxylase 2 Ameliorates Aging-Induced Changes in Mice without Affecting Their Life Span. FASEB Journal, vol. 34, no. 4, 2020, https://doi.org/10.1096/fj.201902331R.


D’Hulst, G., I. Soro-Arnaiz, E. Masschelein, K. Veys, G. Fitzgerald, B. Smeuninx, S. Kim, L. Deldicque, B. Blaauw, P. Carmeliet, L. Breen, P. Koivunen, S. M. Zhao, and K. De Bock. PHD1 Controls Muscle MTORC1 in a Hydroxylation-Independent Manner by Stabilizing Leucyl TRNA Synthetase. Nature Communications, vol. 11, no. 1, 2020, https://doi.org/10.1038/s41467-019-13889-6.


Frye, M., S. Stritt, H. Ortsäter, M. H. Vasquez, M. Kaakinen, A. Vicente, J. Wiseman, L. Eklund, J. L. Martínez-Torrecuadrada, D. Vestweber, and T. Mäkinen. Ephrinb2-Ephb4 Signalling Provides Rho-Mediated Homeostatic Control of Lymphatic Endothelial Cell Junction Integrity. ELife, vol. 9, 2020, https://doi.org/10.7554/ELIFE.57732.


Lähteenvuo, J., O. P. Hätinen, A. Kuivanen, J. Huusko, J. Paananen, M. Lähteenvuo, J. Nurro, M. Hedman, J. Hartikainen, N. Laham-Karam, P. Mäkinen, M. Räsänen, K. Alitalo, A. Rosenzweig, and S. Ylä-Herttuala. Susceptibility to Cardiac Arrhythmias and Sympathetic Nerve Growth in VEGF-B Overexpressing Myocardium. Molecular Therapy, vol. 28, no. 7, 2020, https://doi.org/10.1016/j.ymthe.2020.03.011.


Eklund, A., H. Zhang, H. Zeng, A. Priimagi, and O. Ikkala. Fast Switching of Bright Whiteness in Channeled Hydrogel Networks. Advanced Functional Materials, vol. 30, no. 28, 2020, https://doi.org/10.1002/adfm.202000754.


Martikainen, L., K. Bertula, M. Turunen, and O. Ikkala. Strain Stiffening and Negative Normal Force of Agarose Hydrogels. Macromolecules, vol. 53, no. 22, 2020, https://doi.org/10.1021/acs.macromol.0c00601.


Samoylenko A, Kögler M, Zhyvolozhnyi A, Makieieva O, Bart G, Andoh SS, Roussey M, Vainio SJ, Hiltunen J. Time-gated Raman spectroscopy and proteomics analyses of hypoxic and normoxic renal carcinoma extracellular vesicles. Sci Rep. 2021 Oct 1;11(1):19594. doi: 10.1038/s41598-021-99004-6.


Ullah MS, Zhivonitko VV, Samoylenko A, Zhyvolozhnyi A, Viitala S, Kankaanpää S, Komulainen S, Schröder L, Vainio SJ, Telkki VV. Identification of extracellular nanoparticle subsets by nuclear magnetic resonance. Chem Sci. 2021 Apr 29;12(24):8311-8319. doi: 10.1039/d1sc01402a.


Bart G, Fischer D, Samoylenko A, Zhyvolozhnyi A, Stehantsev P, Miinalainen I, Kaakinen M, Nurmi T, Singh P, Kosamo S, Rannaste L, Viitala S, Hiltunen J, Vainio SJ. Characterization of nucleic acids from extracellular vesicle-enriched human sweat. BMC Genomics. 2021 Jun 9;22(1):425. doi: 10.1186/s12864-021-07733-9.


Monteiro-Reis S, Carvalho-Maia C, Bart G, Vainio SJ, Pedro J, Silva ER, Sales G, Henrique R, Jerónimo C. Secreted Extracellular Vesicle Molecular Cargo as a Novel Liquid Biopsy Diagnostics of Central Nervous System Diseases. Int J Mol Sci. 2021 Mar 23;22(6):3267. doi: 10.3390/ijms22063267.


Andjus P, Kosanović M, Milićević K, Gautam M, Vainio SJ, Jagečić D, Kozlova EN, Pivoriūnas A, Chachques JC, Sakaj M, Brunello G, Mitrecic D, Zavan B. Extracellular Vesicles as Innovative Tool for Diagnosis, Regeneration and Protection against Neurological Damage. Int J Mol Sci. 2020 Sep 18;21(18):6859. doi: 10.3390/ijms21186859.


Rilla K. Diverse plasma membrane protrusions act as platforms for extracellular vesicle shedding. J Extracell Vesicles. 2021 Sep;10(11):e12148. doi: 10.1002/jev2.12148.


Frederik J. Verweij, Leonora Balaj, Chantal M. Boulanger, David R. F. Carter, Ewoud B. Compeer, Gisela D’Angelo, Samir El Andaloussi, Jacky G. Goetz, Julia Christina Gross, Vincent Hyenne, Eva-Maria Krämer-Albers, Charles P. Lai, Xavier Loyer, Alex Marki, Stefan Momma, Esther N. M. Nolte-‘t Hoen, D. Michiel Pegtel, Hector Peinado, Graça Raposo, Kirsi Rilla, Hidetoshi Tahara, Clotilde Théry, Martin E. van Royen, Roosmarijn E. Vandenbroucke, Ann M. Wehman, Kenneth Witwer, Zhiwei Wu, Richard Wubbolts & Guillaume van Niel. The power of imaging to understand extracellular vesicle biology in vivo. Nat Methods (2021). https://doi.org/10.1038/s41592-021-01206-3 The power of imaging to understand extracellular vesicle biology in vivo | Nature Methods


S. Balasubramaniam S, Barros M. T, Veletić M, Kanada M, Pierobon M, Vainio S, Balasingham I. Editorial—Special Issue on Molecular Communications for Diagnostics and Therapeutic Development of Infectious Diseases. IEEE Transactions on Molecular, Biological and Multi-Scale Communications, vol. 7, no. 3, pp. 117-120, Sept. 2021.

Editorial—Special Issue on Molecular Communications for Diagnostics and Therapeutic Development of Infectious Diseases | IEEE Journals & Magazine | IEEE Xplore


Abou-Hassan A, Barros A, Buchholz N, Carugo D, Clavica F, de Graaf P, de La Cruz J, Kram W, Mergulhao F, Reis RL, Skovorodkin I, Soria F, Vainio S, Zheng S. Potential strategies to prevent encrustations on urinary stents and catheters – thinking outside the box: a European network of multidisciplinary research to improve urinary stents (ENIUS) initiative. Expert Rev Med Devices. 2021 Jun 11:1-9. doi: 10.1080/17434440.2021.1939010. https://doi.org/10.1080/17434440.2021.1939010


Tavakoli S, Kari OK, Turunen T, Lajunen T, Schmitt M, Lehtinen J, Tasaka F, Parkkila P, Ndika J, Viitala T, Alenius H, Urtti A, Subrizi A. Diffusion and Protein Corona Formation of Lipid-Based Nanoparticles in the Vitreous Humor: Profiling and Pharmacokinetic Considerations. Mol Pharm. 2021 Feb 1;18(2):699-713. doi: 10.1021/acs.molpharmaceut.0c00411.


Kapiainen E, Kihlström MK, Pietilä R, Kaakinen M, Ronkainen VP, Tu H, Heikkinen A, Devarajan R, Miinalainen I, Laitakari A, Ansarizadeh M, Zhang Q, Wei GH, Ruddock L, Pihlajaniemi T, Elamaa H, Eklund L. The Amino-Terminal Oligomerization Domain of Angiopoietin-2 Affects Vascular Remodeling, Mammary Gland Tumor Growth, and Lung Metastasis in Mice. Cancer Res. 2021 Jan 1;81(1):129-143. doi: 10.1158/0008-5472.CAN-19-1904.

https://cancerres.aacrjournals.org/content/81/1/129.long


Ali N, Rezvani HR, Motei D, Suleman S, Mahfouf W, Marty I, Ronkainen VP, Vainio SJ. Trisk 95 as a novel skin mirror for normal and diabetic systemic glucose level. Sci Rep. 2020 Jul 22;10(1):12246. doi: 10.1038/s41598-020-68972-6.

https://www.nature.com/articles/s41598-020-68972-6


Gurvich OL, Puttonen KA, Bailey A, Kailaanmäki A, Skirdenko V, Sivonen M, Pietikäinen S, Parker NR, Ylä-Herttuala S, Kekarainen T. Transcriptomics uncovers substantial variability associated with alterations in manufacturing processes of macrophage cell therapy products. Sci Rep. 2020 Aug 20;10(1):14049. doi: 10.1038/s41598-020-70967-2.

https://www.nature.com/articles/s41598-020-70967-2


Adnan Awad S, Dufva O, Ianevski A, Ghimire B, Koski J, Maliniemi P, Thomson D, Schreiber A, Heckman CA, Koskenvesa P, Korhonen M, Porkka K, Branford S, Aittokallio T, Kankainen M, Mustjoki S. RUNX1 mutations in blast-phase chronic myeloid leukemia associate with distinct phenotypes, transcriptional profiles, and drug responses. Leukemia. 2020 Aug 11. doi: 10.1038/s41375-020-01011-5.

https://www.nature.com/articles/s41375-020-01011-5


Schenkwein D, Afzal S, Nousiainen A, Schmidt M, Ylä-Herttuala S. Efficient Nuclease-Directed Integration of Lentivirus Vectors into the Human Ribosomal DNA Locus. Mol Ther. 2020 Aug 5;28(8):1858-1875. doi: 10.1016/j.ymthe.2020.05.019.

https://www.sciencedirect.com/science/article/pii/S1525001620302537?via%3Dihub


Saari H, Turunen T, Lõhmus A, Turunen M, Jalasvuori M, Butcher SJ, Ylä-Herttuala S, Viitala T, Cerullo V, Siljander PRM, Yliperttula M. Extracellular vesicles provide a capsid-free vector for oncolytic adenoviral DNA delivery. J Extracell Vesicles. 2020 Apr 17;9(1):1747206. doi: 10.1080/20013078.2020.1747206.

https://onlinelibrary.wiley.com/doi/10.1080/20013078.2020.1747206


Dufva O, Koski J, Maliniemi P, Ianevski A, Klievink J, Leitner J, Pölönen P, Hohtari H, Saeed K, Hannunen T, Ellonen P, Steinberger P, Kankainen M, Aittokallio T, Keränen MAI, Korhonen M, Mustjoki S. Integrated drug profiling and CRISPR screening identify essential pathways for CAR T-cell cytotoxicity. Blood. 2020 Feb 27;135(9):597-609. doi: 10.1182/blood.2019002121.

https://ashpublications.org/blood/article/135/9/597/429647/Integrated-drug-profiling-and-CRISPR-screening