Selected publications from the GeneCellNano Flagship:
Valkama, E., A. Sadeghi, E. Toropainen, O. Perez, N. Schipper, M. Ruponen, A. Urtti, and T. Lajunen. Drug Release and Pharmacokinetics of Intravitreal Liposomal Injections: A Case Study with Cyclic Guanosine Monophosphate Derivative. European Journal of Pharmaceutical Sciences, vol. 214, Nov. 2025, p. 107291. https://doi.org/10.1016/j.ejps.2025.107291.
Mavali Zadeh, A., E. Gatto, R. Lettieri, H. Bokharaie, A. Caravella, C. D’Ottavi, E. di Bartolomeo, F. Domenici, S. Sima, A. Correia, K. Rauniyar, A. Klose, Z. Gounani, T. Laaksonen, J. Künnapuu, and M. Jeltsch. Biomass-Derived Lignin Nanoparticles for the Sustained Delivery of Vascular Endothelial Growth Factor-C. European Journal of Pharmaceutics and Biopharmaceutics, vol. 216, Nov. 2025, p. 114860. https://doi.org/10.1016/j.ejpb.2025.114860.
Seitz, I., D. McNeale, F. Sainsbury, V. Linko, and M. A. Kostiainen. Modular Virus Capsid Coatings for Biocatalytic DNA Origami Nanoreactors. ACS Nano, vol. 19, no. 41, Oct. 2025, pp. 36465–77. https://doi.org/10.1021/acsnano.5c10734.
Shanthi, K. B., F. W. Pratiwi, F. Naillat, R. Mammadova, M. Sarpola, S.-H. Wu, M. Suokas, S. Jokipii-Lukkari, S. Kaisto, A. Samoylenko, H. Liimatainen, C. Elbuken, and S. J. Vainio. Cloudberry-Derived Nanovesicles as Stable Oral Drug Delivery Systems: Gastrointestinal Stability and Age-Related Biodistribution in Mice. Nanoscale, vol. 17, no. 36, Sept. 2025, pp. 21096–111. https://doi.org/10.1039/D4NR04694C.
Raik, S., V. Aseyev, E. Vuorimaa-Laukkanen, S. Tavakoli, C. Yetgin, T. Laaksonen, and A. Urtti. Chitosan – Hyaluronate Based Polyplexes for the Delivery of Oligonucleotides: Structural Properties and Intravitreal Mobility. Carbohydrate Polymers, vol. 366, Oct. 2025, p. 123920. https://doi.org/10.1016/j.carbpol.2025.123920.
Kurkela, M., L. Dvořáková, H. Koivisto, M. Uusitalo, P. Kursula, M. Kettunen, O. Gröhn, H. Tanila, and P. Koivunen. Targeting HIF-P4H-2 in APP/PS1 Alzheimer’s Mouse Model Improves Glucose Metabolism, Reduces Dystrophic Neuritis, and Maintains Exploratory Activity. The Journal of Biological Chemistry, vol. 301, no. 8, July 2025, p. 110432. https://doi.org/10.1016/j.jbc.2025.110432.
Stenberg, K., S. Korhonen, U. Seemab, D. M. Dupont, J. Kjems, P. Honkakoski, and A. Subrizi. Selection of Locally Administered Ocular Tissue-Targeting RNA Aptamers Using in Vivo SELEX. European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for Pharmaceutical Sciences, vol. 212, July 2025, p. 107217. https://doi.org/10.1016/j.ejps.2025.107217.
Abdorahimzadeh, S., É. Bozó, Z. Bölükkaya, A. Zhyvolozhnyi, A. Samoylenko, H. Liimatainen, S. J. Vainio, and C. Elbuken. Microfluidic Electro-Viscoelastic Manipulation of Extracellular Vesicles. FEBS Open Bio, July 2025. https://doi.org/10.1002/2211-5463.70080.
Lisitsyna, E. S., A. Klose, E. Vuorimaa-Laukkanen, H. Ijäs, T. Lajunen, K. Suhling, V. Linko, and T. Laaksonen. Fluorescence Anisotropy for Detailed Analysis of Doxorubicin Loading into DNA Origami Nanocarriers for Drug Delivery. ACS Applied Nano Materials, vol. 8, no. 26, July 2025, pp. 13274–84. https://doi.org/10.1021/acsanm.5c01518.
Kröger, A., J. Monola, R. Harjumäki, T. Rojalin, A. Koivuniemi, A. Niemelä, K. Svedström, H. Suhonen, S. Huotari, O. Korhonen, E. Koivunotko, and M. Yliperttula. Raman Spectroscopy Reveals Characteristics of Sugar Excipients in Freeze-Drying of Nanofibrillated Cellulose. International Journal of Pharmaceutics, vol. 682, June 2025, p. 125900. https://doi.org/10.1016/j.ijpharm.2025.125900.
Sorsa, T., E. M. del Amo, A. Sadeghi, J. Laitinen, I. Pilipenko, A. Urtti, and A. Subrizi. Novel in Vitro Model for Intravitreal Drug Dissolution and Release Studies of Small Molecules and Their Long-Acting Formulations. Journal of Controlled Release, vol. 383, July 2025, p. 113823. https://doi.org/10.1016/j.jconrel.2025.113823.
Pilipenko, I., T. Sorsa, A. Valtari, S. Posio, K.-S. Vellonen, A. Subrizi, S. Hietala, M. Ruponen, and A. Urtti. Thermoresponsive Hydrogels with Tunable Viscoelasticity for Extended Ocular Drug Delivery. Biomacromolecules, vol. 26, no. 6, June 2025, pp. 3721–31. https://doi.org/10.1021/acs.biomac.5c00292.
Kettunen, S., A. Slita, T. Suoranta, I. Räty, S. Laidinen, E. Ylä-Herttuala, A.-K. Ruotsalainen, and S. Ylä-Herttuala. Myocardial Infarction Activates the 9p21.3 Orthologous Locus Expression, but Its Absence Does Not Alter Cardiac Pathophysiology in Ischemia. Physiological Reports, vol. 13, no. 10, May 2025, p. e70344. https://doi.org/10.14814/phy2.70344.
Savolainen, H., N. Hosseiniyan, M. Piedrahita-Bello, and O. Ikkala. Bioinspired Nondissipative Mechanical Energy Storage and Release in Hydrogels via Hierarchical Sequentially Swollen Stretched Chains. Nature Communications, vol. 16, no. 1, May 2025, p. 4544. https://doi.org/10.1038/s41467-025-59743-w.
Mallick, R., A. B. Montaser, H. Komi, G. Juusola, A. Tirronen, E. Gurzeler, M. Barbiera, P. Korpisalo, T. Terasaki, T. Nieminen, and S. Ylä-Herttuala. VEGF-B Is a Novel Mediator of ER Stress Which Induces Cardiac Angiogenesis via RGD-Binding Integrins Independent of VEGFR1/NRP Activities. Molecular Therapy, Mar. 2025, pp. S1525-0016(25)00186-8. https://doi.org/10.1016/j.ymthe.2025.03.012.
Petrov, P., and V. Izzi. ProToDeviseR: An Automated Protein Topology Scheme Generator. BMC Bioinformatics, vol. 26, no. 1, Mar. 2025, p. 71. https://doi.org/10.1186/s12859-025-06088-2.
Seitz, I., S. Saarinen, J. Wierzchowiecka, E.-P. Kumpula, B. Shen, J. J. L. M. Cornelissen, V. Linko, J. T. Huiskonen, and M. A. Kostiainen. Folding of MRNA-DNA Origami for Controlled Translation and Viral Vector Packaging. Advanced Materials, Feb. 2025, p. e2417642. https://doi.org/10.1002/adma.202417642.
Ansarizadeh, M., H.-T. Nguyen, B. Lazovic, J. Kettunen, L. D. Silva, R. Sivakumar, P. Junttila, S.-L. Rissanen, R. Hicks, P. Singh, and L. Eklund. Microfluidic Vessel-on-Chip Platform for Investigation of Cellular Defects in Venous Malformations and Responses to Various Shear Stress and Flow Conditions. Lab on a Chip, vol. 25, no. 4, Feb. 2025, pp. 613–30. https://doi.org/10.1039/D4LC00824C.
Valtari, A., S. Kalinin, J. Jäntti, P. Vanhanen, M. Hanzlikova, A. Tonduru, K. Stenberg, T. Viitala, K.-S. Vellonen, E. Toropainen, M. Ruponen, and A. Urtti. Melanin-Binding-Based Discovery of Topically Instilled Carbonic Anhydrase Inhibitors for Targeted Delivery and Prolonged Action in the Eye. Molecular Pharmaceutics, vol. 22, no. 2, Feb. 2025, pp. 721–32. https://doi.org/10.1021/acs.molpharmaceut.4c00694.
Hytönen, J. P., J. Pajula, P. Halonen, J. Taavitsainen, A. Kuivanen, S. Tarvainen, M. Heikkilä, P. Mäkinen, A. Koistinen, J. P. Laakkonen, J. Hartikainen, and S. Ylä-Herttuala. Endothelialization of Coronary Stents after Intra-Luminal Adenoviral VEGF-A Gene Transfer in a Preclinical Porcine Restenosis Model – Studies with Optical Coherence Tomography, Angioscopy, Multiphoton and Scanning Electron Microscopy. Journal of Molecular and Cellular Cardiology, vol. 199, Feb. 2025, pp. 118–25. https://doi.org/10.1016/j.yjmcc.2024.12.007.
Ranjan, S., S. Bosch, H. Lukkari, J. Schirmer, N. Aaltonen, H. J. Nieminen, V.-P. Lehto, A. Urtti, T. Lajunen, and K. Rilla. Development of Focused Ultrasound-Assisted Nanoplexes for RNA Delivery. Nanomaterials, vol. 14, no. 13, June 2024, p. 1089. https://doi.org/10.3390/nano14131089.
Narayan, V. M., S. A. Boorjian, M. Alemozaffar, B. R. Konety, N. D. Shore, L. G. Gomella, A. M. Kamat, T. J. Bivalacqua, J. S. Montgomery, S. P. Lerner, J. E. Busby, M. Poch, P. L. Crispen, G. D. Steinberg, A. K. Schuckman, T. M. Downs, J. Mashni, B. R. Lane, G. Bratslavsky, L. I. Karsh, M. E. Woods, G. Brown, D. Canter, A. Luchey, Y. Lotan, B. A. Inman, M. B. Williams, M. S. Cookson, S. S. Chang, A. I. Sankin, M. A. O’Donnell, D. Sawutz, R. Philipson, N. R. Parker, S. Yla-Herttuala, D. Rehm, J. S. Jakobsen, K. Juul, and C. P. N. Dinney. Efficacy of Intravesical Nadofaragene Firadenovec for Patients With Bacillus Calmette-Guérin-Unresponsive Nonmuscle-Invasive Bladder Cancer: 5-Year Follow-up From a Phase 3 Trial. The Journal of Urology, May 2024, p. 101097JU0000000000004020. https://doi.org/10.1097/JU.0000000000004020.
Merivaara, A., J. Puranen, A. Sadeghi, N. Zashikhina, L. Pirskanen, T. Lajunen, T. Terasaki, S. Auriola, K.-S. Vellonen, and A. Urtti. Barcode Lipids for Absolute Quantitation of Liposomes in Ocular Tissues. Journal of Controlled Release, vol. 370, Apr. 2024, pp. 1–13. https://doi.org/10.1016/j.jconrel.2024.04.023.
Zwirner, S., A. A. Abu Rmilah, S. Klotz, B. Pfaffenroth, P. Kloevekorn, A. A. Moschopoulou, S. Schuette, M. Haag, R. Selig, K. Li, W. Zhou, E. Nelson, A. Poso, H. Chen, B. Amiot, Y. Jia, A. Minshew, G. Michalak, W. Cui, E. Rist, T. Longerich, B. Jung, P. Felgendreff, O. Trompak, P. K. Premsrirut, K. Gries, T. E. Muerdter, G. Heinkele, T. Wuestefeld, D. Shapiro, M. Weissbach, A. Koenigsrainer, B. Sipos, E. Ab, M. O. Zacarias, S. Theisgen, N. Gruenheit, S. Biskup, M. Schwab, W. Albrecht, S. Laufer, S. Nyberg, and L. Zender. First-in-Class MKK4 Inhibitors Enhance Liver Regeneration and Prevent Liver Failure. Cell, Mar. 2024, pp. S0092-8674(24)00225-3. https://doi.org/10.1016/j.cell.2024.02.023.
Ilvonen, P., R. Pusa, K. Härkönen, S. Laitinen, and U. Impola. Distinct Targeting and Uptake of Platelet and Red Blood Cell-Derived Extracellular Vesicles into Immune Cells. Journal of Extracellular Biology, vol. 3, no. 1, Jan. 2024, p. e130. https://doi.org/10.1002/jex2.130.
Lampela, J., J. Pajula, N. Järveläinen, S. Siimes, N. Laham-Karam, A. Kivelä, I. Mushimiyimana, J. Nurro, J. Hartikainen, and S. Ylä-Herttuala. Cardiac Vein Retroinjections Provide an Efficient Approach for Global Left Ventricular Gene Transfer with Adenovirus and Adeno-Associated Virus. Scientific Reports, vol. 14, no. 1, Jan. 2024, p. 1467. https://doi.org/10.1038/s41598-024-51712-5.
Hu, S., Y. Fang, C. Liang, M. Turunen, O. Ikkala, and H. Zhang. Thermally Trainable Dual Network Hydrogels. Nature Communications, vol. 14, no. 1, June 2023, p. 3717. https://doi.org/10.1038/s41467-023-39446-w.
Beter, M., A. Abdollahzadeh, H. H. Pulkkinen, H. Huang, F. Orsenigo, P. U. Magnusson, S. Ylä-Herttuala, J. Tohka, and J. P. Laakkonen. SproutAngio: An Open-Source Bioimage Informatics Tool for Quantitative Analysis of Sprouting Angiogenesis and Lumen Space. Scientific Reports, vol. 13, no. 1, May 2023, p. 7279. https://doi.org/10.1038/s41598-023-33090-6.
Rahat, S. T., M. Mäkelä, M. Nasserinejad, T. M. Ikäheimo, H. Hyrkäs-Palmu, R. I. P. Valtonen, J. Röning, S. Sebert, A. I. Nieminen, N. Ali, and S. Vainio. Clinical-Grade Patches as a Medium for Enrichment of Sweat-Extracellular Vesicles and Facilitating Their Metabolic Analysis. International Journal of Molecular Sciences, vol. 24, no. 8, 8, Jan. 2023, p. 7507. https://doi.org/10.3390/ijms24087507.
Ali, N., S. T. Rahat, M. Mäkelä, M. Nasserinejad, T. Jaako, M. Kinnunen, J. Schroderus, M. Tulppo, A. I. Nieminen, and S. Vainio. Metabolic Patterns of Sweat-Extracellular Vesicles during Exercise and Recovery States Using Clinical Grade Patches. Frontiers in Physiology, vol. 14, 2023, p. 1295852. https://doi.org/10.3389/fphys.2023.1295852.
Merivaara, A., E. Koivunotko, K. Manninen, T. Kaseva, J. Monola, E. Salli, R. Koivuniemi, S. Savolainen, S. Valkonen, and M. Yliperttula. Stiffness-Controlled Hydrogels for 3D Cell Culture Models. Polymers, vol. 14, no. 24, Dec. 2022. https://doi.org/10.3390/polym14245530.
Auvinen, V.-V., P. Laurén, B. Shen, J. Isokuortti, N. Durandin, T. Lajunen, V. Linko, and T. Laaksonen. Nanoparticle Release from Anionic Nanocellulose Hydrogel Matrix. Cellulose, vol. 29, no. 18, Dec. 2022, pp. 9707–17. https://doi.org/10.1007/s10570-022-04875-1.
Zhang, H., H. Zeng, A. Eklund, H. Guo, A. Priimagi, and O. Ikkala. Feedback-Controlled Hydrogels with Homeostatic Oscillations and Dissipative Signal Transduction. Nature Nanotechnology, vol. 17, no. 12, Dec. 2022, pp. 1303–10. https://doi.org/10.1038/s41565-022-01241-x.
Tonduru, A. K., S. K. Adla, K. M. Huttunen, T. Kronenberger, and A. Poso. Comparative Modelling of Organic Anion Transporting Polypeptides: Structural Insights and Comparison of Binding Modes. Molecules (Basel, Switzerland), vol. 27, no. 23, Dec. 2022. https://doi.org/10.3390/molecules27238531.
Korpela, H., J. Lampela, J. Airaksinen, N. Järveläinen, S. Siimes, K. Valli, T. Nieminen, M. Turunen, M. Grönman, A. Saraste, J. Knuuti, M. Hakulinen, P. Poutiainen, V. Kärjä, J. Nurro, and S. Ylä-Herttuala. AAV2-VEGF-B Gene Therapy Failed to Induce Angiogenesis in Ischemic Porcine Myocardium Due to Inflammatory Responses. Gene Therapy, vol. 29, no. 10–11, Nov. 2022, pp. 643–52, https://doi.org/10.1038/s41434-022-00322-9.
Kapiainen, E., H. Elamaa, I. Miinalainen, V. Izzi, and L. Eklund. Cooperation of Angiopoietin-2 and Angiopoietin-4 in Schlemm’s Canal Maintenance. Investigative Ophthalmology & Visual Science, vol. 63, no. 11, Oct. 2022, p. 1. https://doi.org/10.1167/iovs.63.11.1.
Koivunotko, E., J. Snirvi, A. Merivaara, R. Harjumäki, S. Rautiainen, M. Kelloniemi, K. Kuismanen, S. Miettinen, M. Yliperttula, and R. Koivuniemi. Angiogenic Potential of Human Adipose-Derived Mesenchymal Stromal Cells in Nanofibrillated Cellulose Hydrogel. Biomedicines, vol. 10, no. 10, Oct. 2022. https://doi.org/10.3390/biomedicines10102584.
Leikas, A. J., I. Hassinen, A. Kivelä, A. Hedman, H. Mussalo, S. Ylä-Herttuala, and J. E. K. Hartikainen. Intramyocardial Adenoviral Vascular Endothelial Growth Factor-D(∆N∆C) Gene Therapy Does Not Induce Ventricular Arrhythmias. The Journal of Gene Medicine, vol. 24, no. 8, Aug. 2022, p. e3437. https://doi.org/10.1002/jgm.3437.
Tapio, J., R. Halmetoja, E. Y. Dimova, J. M. Mäki, A. Laitala, G. Walkinshaw, J. Myllyharju, R. Serpi, and P. Koivunen. Contribution of HIF-P4H Isoenzyme Inhibition to Metabolism Indicates Major Beneficial Effects Being Conveyed by HIF-P4H-2 Antagonism. The Journal of Biological Chemistry, vol. 298, no. 8, Aug. 2022, p. 102222. https://doi.org/10.1016/j.jbc.2022.102222.
Jauhiainen, S., M. Kiema, M. Hedman, and J. P. Laakkonen. Large Vessel Cell Heterogeneity and Plasticity: Focus in Aortic Aneurysms. Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 42, no. 7, July 2022, pp. 811–18. https://doi.org/10.1161/ATVBAHA.121.316237.
Koski, J., F. Jahan, A. Luostarinen, D. Schenkwein, S. Ylä-Herttuala, H. Göös, H. Monzo, P. M. Ojala, P. Maliniemi, and M. Korhonen. Novel Modular Chimeric Antigen Receptor Spacer for T Cells Derived from Signal Regulatory Protein Alpha Ig-like Domains. Frontiers in Molecular Medicine, vol. 2, 2022. https://www.frontiersin.org/articles/10.3389/fmmed.2022.1049580.
Kiema, M., J. K. Sarin, S. P. Kauhanen, J. Torniainen, H. Matikka, E.-S. Luoto, P. Jaakkola, P. Saari, T. Liimatainen, R. Vanninen, S. Ylä-Herttuala, M. Hedman, and J. P. Laakkonen. Wall Shear Stress Predicts Media Degeneration and Biomechanical Changes in Thoracic Aorta. Frontiers in Physiology, vol. 13, 2022, p. 934941, https://doi.org/10.3389/fphys.2022.934941.
Linko, V., H. Zhang, Nonappa, M. A. Kostiainen, and O. Ikkala. From Precision Colloidal Hybrid Materials to Advanced Functional Assemblies. Accounts of Chemical Research, vol. 55, no. 13, July 2022, pp. 1785–95, https://doi.org/10.1021/acs.accounts.2c00093.
Zini, J., H. Saari, P. Ciana, T. Viitala, A. Lõhmus, J. Saarinen, and M. Yliperttula. Infrared and Raman Spectroscopy for Purity Assessment of Extracellular Vesicles. European Journal of Pharmaceutical Sciences, vol. 172, May 2022, p. 106135, https://doi.org/10.1016/j.ejps.2022.106135.
Tavakoli, S., J. Puranen, S. Bahrpeyma, V. E. Lautala, S. Karumo, T. Lajunen, E. M. Del Amo, M. Ruponen, and A. Urtti. Liposomal Sunitinib for Ocular Drug Delivery: A Potential Treatment for Choroidal Neovascularization. International Journal of Pharmaceutics, vol. 620, May 2022, p. 121725, https://doi.org/10.1016/j.ijpharm.2022.121725.
Elamaa, H., M. Kaakinen, M. Nätynki, Z. Szabo, V.-P. Ronkainen, V. Äijälä, J. M. Mäki, R. Kerkelä, J. Myllyharju, and L. Eklund. PHD2 Deletion in Endothelial or Arterial Smooth Muscle Cells Reveals Vascular Cell Type-Specific Responses in Pulmonary Hypertension and Fibrosis. Angiogenesis, vol. 25, no. 2, May 2022, pp. 259–74, https://doi.org/10.1007/s10456-021-09828-z.
Rak-Raszewska, A., G. Reint, F. Geiger, F. Naillat, and S. J. Vainio. Deciphering the Minimal Quantity of Mouse Primary Cells to Undergo Nephrogenesis Ex Vivo. Developmental Dynamics, vol. 251, no. 3, Mar. 2022, pp. 536–50, https://doi.org/10.1002/dvdy.418.
Korpela, H., O.-P. Hätinen, T. Nieminen, R. Mallick, P. Toivanen, J. Airaksinen, K. Valli, M. Hakulinen, P. Poutiainen, J. Nurro, and S. Ylä-Herttuala. Adenoviral VEGF-B186R127S Gene Transfer Induces Angiogenesis and Improves Perfusion in Ischemic Heart. IScience, vol. 24, no. 12, Dec. 2021, p. 103533, https://doi.org/10.1016/j.isci.2021.103533.
Järveläinen, N., P. Halonen, J. Nurro, O.-P. Hätinen, H. Korpela, P. Mäkinen, L.-M. Gan, R. Fritsche-Danielson, and S. Ylä-Herttuala. Citrate-Saline-Formulated MRNA Delivery into the Heart Muscle with an Electromechanical Mapping and Injection Catheter Does Not Lead to Therapeutic Effects in a Porcine Chronic Myocardial Ischemia Model. Human Gene Therapy, vol. 32, no. 19–20, Oct. 2021, pp. 1295–307, https://doi.org/10.1089/hum.2021.149.
Mushimiyimana, I., H. Niskanen, M. Beter, J. P. Laakkonen, M. U. Kaikkonen, S. Ylä-Herttuala, and N. Laham-Karam. Characterization of a Functional Endothelial Super-Enhancer That Regulates ADAMTS18 and Angiogenesis. Nucleic Acids Research, vol. 49, no. 14, Aug. 2021, pp. 8078–96, https://doi.org/10.1093/nar/gkab633.
Leikas, A. J., N. Laham-Karam, E. Agtereek, H. M. Peltonen, T. Selander, P. Korpisalo, L. Holappa, J. E. K. Hartikainen, T. Heikura, and S. Ylä-Herttuala. Efficacy and Safety of Clinical-Grade Human Vascular Endothelial Growth Factor-D(ΔNΔC) Gene Therapy Containing Residual Replication-Competent Adenoviruses. Human Gene Therapy, vol. 32, no. 13–14, July 2021, pp. 761–70, https://doi.org/10.1089/hum.2020.299.
Määttä, J., R. Serpi, S. Hörkkö, V. Izzi, J. Myllyharju, E. Y. Dimova, and P. Koivunen. Genetic Ablation of Transmembrane Prolyl 4-Hydroxylase Reduces Atherosclerotic Plaques in Mice. Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 41, no. 7, July 2021, pp. 2128–40, https://doi.org/10.1161/ATVBAHA.121.316034.
Auvinen, J., J. Tapio, V. Karhunen, J. Kettunen, R. Serpi, E. Y. Dimova, D. Gill, P. Soininen, T. Tammelin, J. Mykkänen, K. Puukka, M. Kähönen, E. Raitoharju, T. Lehtimäki, M. Ala-Korpela, O. T. Raitakari, S. Keinänen-Kiukaanniemi, M.-R. Järvelin, and P. Koivunen. Systematic Evaluation of the Association between Hemoglobin Levels and Metabolic Profile Implicates Beneficial Effects of Hypoxia. Science Advances, vol. 7, no. 29, July 2021, https://doi.org/10.1126/sciadv.abi4822.
Leikas, A. J., I. Hassinen, A. Hedman, A. Kivelä, S. Ylä-Herttuala, and J. E. K. Hartikainen. Long-Term Safety and Efficacy of Intramyocardial Adenovirus-Mediated VEGF-D(ΔNΔC) Gene Therapy Eight-Year Follow-up of Phase I KAT301 Study. Gene Therapy, vol. 29, no. 5, May 2022, pp. 289–93, https://doi.org/10.1038/s41434-021-00295-1.
Sadeghi, A., J. Puranen, M. Ruponen, A. Valtari, A. Subrizi, V.-P. Ranta, E. Toropainen, and A. Urtti. Pharmacokinetics of Intravitreal Macromolecules: Scaling between Rats and Rabbits. European Journal of Pharmaceutical Sciences , vol. 159, Apr. 2021, p. 105720, https://doi.org/10.1016/j.ejps.2021.105720.
Pulkkinen, H. H., M. Kiema, J. P. Lappalainen, A. Toropainen, M. Beter, A. Tirronen, L. Holappa, H. Niskanen, M. U. Kaikkonen, S. Ylä-Herttuala, and J. P. Laakkonen. BMP6/TAZ-Hippo Signaling Modulates Angiogenesis and Endothelial Cell Response to VEGF. Angiogenesis, vol. 24, no. 1, Feb. 2021, pp. 129–44, https://doi.org/10.1007/s10456-020-09748-4.
Tavakoli, S., O. K. Kari, T. Turunen, T. Lajunen, M. Schmitt, J. Lehtinen, F. Tasaka, P. Parkkila, J. Ndika, T. Viitala, H. Alenius, A. Urtti, and A. Subrizi. Diffusion and Protein Corona Formation of Lipid-Based Nanoparticles in the Vitreous Humor: Profiling and Pharmacokinetic Considerations. Molecular Pharmaceutics, vol. 18, no. 2, Feb. 2021, pp. 699–713, https://doi.org/10.1021/acs.molpharmaceut.0c00411.
Kapiainen, E., M. K. Kihlström, R. Pietilä, M. Kaakinen, V.-P. Ronkainen, H. Tu, A. Heikkinen, R. Devarajan, I. Miinalainen, A. Laitakari, M. Ansarizadeh, Q. Zhang, G.-H. Wei, L. Ruddock, T. Pihlajaniemi, H. Elamaa, and L. Eklund. The Amino-Terminal Oligomerization Domain of Angiopoietin-2 Affects Vascular Remodeling, Mammary Gland Tumor Growth, and Lung Metastasis in Mice. Cancer Research, vol. 81, no. 1, Jan. 2021, pp. 129–43, https://doi.org/10.1158/0008-5472.CAN-19-1904.
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